通过上皮细胞滑动形成神经感官器官
Christin S Kuo1, Mark A Krasnow2
1Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307, USA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305-5307, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305-5307, USA.
Cell
|October 6, 2015
概括
研究人员在肺部神经皮质体的形成过程中发现了一种新的细胞迁移过程, 这种有针对性的细胞移动可能解释了某些肺癌的高转移潜力.
科学领域:
- 发育生物学
- 细胞生物学
- 肺部研究
背景情况:
- 表皮细胞保持稳定的位置和底层膜协会.
- 细胞重组是通过间隔,分层或上皮-介质过渡发生的.
- 肺神经上皮体 (NEB) 是支气管上皮体内的内集群.
研究的目的:
- 绘制肺神经皮质体 (NEB) 的形成.
- 确定和描述NEB发育中的细胞迁移机制.
- 探索这种机制对神经内分泌肺癌转移的影响.
主要方法:
- 免疫增强
- 血统追踪
- 克隆分析
- 现场成像
主要成果:
- 发现了一种新的细胞迁移模式,称为"滑动".
- NEB的原始细胞暂时失去上皮质特征,在细胞之间迁移.
- 原始体聚集在气管分支点,重新建立上皮结构,并表达神经内分泌基因.
- 在NEB形成过程中观察到很少的原生细胞增殖或亡.
结论:
- 对于NEB的发展至关重要.
- 这种有针对性的迁移涉及粘附和极性蛋白的下调.
- 这种滑动机制可能是神经内分泌肺癌转移的基础.
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