类纳米片呈现出新的二次结构图案
Ranjan V Mannige1, Thomas K Haxton1, Caroline Proulx1
1Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94709, USA.
Nature
|October 8, 2015
概括
序列定义的类聚合物形成了具有独特的齐克扎克结构的新2D纳米板. 这些蛋白模拟材料具有潜在的孔隙性,并为先进的功能材料提供新的设计原则.
科学领域:
- 材料科学
- 聚合物化学
- 生物模拟化学
背景情况:
- 序列定义的类聚合物是具有复杂功能的蛋白模仿材料.
- 类药物具有无毒性和耐腐蚀性等优点.
- 目前对可访问的形结构和类似蛋白质的架构设计的理解有限.
研究的目的:
- 确定最近发现的状纳米板的原子分辨率结构.
- 研究这些二维超分子组件的结构和动态特性.
- 探索类纳米片的形成原理和潜在应用.
主要方法:
- 使用了分子动力学模拟.
- 散射和显微镜数据与模拟相结合.
- 分析的重点是原子分辨率结构和动态异质性.
主要成果:
- 类纳米片在结构和动态上是异质的.
- 纳米板的形成取决于特定的片长度.
- 一种新型的二次结构,S-链 (曲模式),通过对立的脊柱单体旋转状态实现2D组装.
- 由此产生的 Σ 板结构对水和离子具有潜在的多孔性.
结论:
- 发现的 Σ 链和 Σ 叶结构是独一无二的,在自然蛋白质中没有观察到.
- 类纳米片是一种具有可调节性质的新型蛋白模仿材料.
- 使用多个旋转状态来构建正规结构的原理可以推广到其他聚合物系统.
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