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在生长激素治疗中的伦理问题
J Lantos1, M Siegler, L Cuttler
1Department of Pediatrics, University of Chicago, Pritzker School of Medicine, IL 60637.
JAMA
|February 17, 1989
概括
没有GH缺乏症的矮小儿童的生长激素 (GH) 治疗存在道德挑战. 这种治疗应该是临床研究的一部分,而不是常规护理,因为益处和风险不确定.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 医学伦理 医学伦理
- 儿童健康政策 儿童健康政策
背景情况:
- 儿科医生面临着关于生长激素 (GH) 治疗低矮儿童缺乏经典GH缺乏标准的伦理困境.
- 生物健康规范不足以评估GH疗法,原因是身高,GH分泌,健康和疾病之间的复杂关系.
研究的目的:
- 为了评估GH治疗的伦理考虑,短小的孩子没有记录GH缺乏症.
- 为了比较小矮正常儿童的GH疗法与其他非危及生命的儿科疾病的公认治疗方法.
主要方法:
- 对围绕GH治疗的临床和伦理困境的分析.
- 将GH疗法与已建立的儿科护理模式进行比较 (健康儿童护理,化疗法,心理治疗,慢性疾病管理).
主要成果:
- 对于没有记录的缺乏症的矮小儿童进行GH疗法,由于治疗负担,不确定的长期结果和不清楚的终点,引起了伦理方面的担忧.
- 目前的儿科伦理规范不支持对这些儿童进行常规的GH治疗.
结论:
- 没有经过记录的GH缺乏症的矮小儿童的常规GH治疗超出了当前的儿科伦理标准.
- 这种疗法应在全面的临床研究方案中进行,以解决伦理和安全方面的问题.
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