结构功能分析确定了Striga中高度敏感的strigolactone受体
Shigeo Toh1, Duncan Holbrook-Smith1, Peter J Stogios2
1Cell and Systems Biology, University of Toronto, 25 Willcocks Street, Toronto M5S 3B2, Canada.
Science (New York, N.Y.)
|October 10, 2015
概括
由于结合口袋较大,Striga hermonthica的结合体受体具有较高的敏感性. 这一发现使得一种新的生物测试能够识别改变菌素的化学物质和作物.
科学领域:
- 植物生物学
- 分子生物学
- 生物化学
背景情况:
- 甲是调节植物发育和相互作用的关键信号分子.
- 像Striga hermonthica这样的寄生植物依赖于杆菌来感染宿主植物.
研究的目的:
- 描述Striga hermonthica中球蛋白受体的功能和敏感性.
- 阐明寄生植物对菌素敏感性的结构基础.
主要方法:
- 使用化学和结构生物学技术.
- 来自Striga hermonthica的11个强光素受体的功能性表征.
- 一个高度敏感的Striga强光素受体的晶体结构的确定.
主要成果:
- 在Striga中确定了一类多特异性strigolactone受体.
- 发现一种对皮科莫尔度敏感的受体.
- 与阿拉比多普西斯相比,在Striga受体中发现了一个更大的结合口袋,解释了增强的敏感性.
结论:
- 斯特里加对宿主斯特里戈拉克的敏感性是由其高度敏感的受体介导的.
- 受体的结构差异有助于变异性激素的敏感性.
- 使用Arabidopsis中的Striga受体进行生物试验,以识别影响strigolactone水平的化学物质和作物.
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