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Updated: May 5, 2026

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
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Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

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侵袭性叶状乳腺癌的综合分子肖像

Giovanni Ciriello1, Michael L Gatza2, Andrew H Beck3

  • 1Department of Medical Genetics, University of Lausanne (UNIL), 1011 Lausanne, Switzerland; Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

Cell
|October 10, 2015
PubMed
概括

这项研究揭示了侵袭性叶状癌 (ILC) 的新遗传驱动因素,这是常见的乳腺癌亚型. 这些发现包括PTEN,TBX3和FOXA1突变,提供了潜在的新治疗点.

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Tumor Progression02:07

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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