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Updated: Apr 1, 2026

Single-Molecule Imaging of Lateral Mobility and Ion Channel Activity in Lipid Bilayers using Total Internal Reflection Fluorescence TIRF Microscopy
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通过电子冷显微镜揭示了InsP3R通道的门机械

Guizhen Fan1, Matthew L Baker2, Zhao Wang2

  • 1Department of Biochemistry and Molecular Biology, Structural Biology Imaging Center, The University of Texas Medical School at Houston, 6431 Fannin Street, Houston, Texas 77030, USA.

Nature
|October 13, 2015
PubMed
概括

研究人员揭示了因诺-1,4,5-三酸盐受体 (InsP3Rs) 的近原子结构,这些受体对信号传递至关重要. 独特的螺旋结构表明了调节这些重要离子通道的新机制.

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