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避开矛盾的MAPK通路激活的RAF抑制剂

Chao Zhang1, Wayne Spevak1, Ying Zhang1

  • 1Plexxikon Inc., 91 Bolivar Drive, Berkeley, California 94710, USA.

Nature
|October 16, 2015
PubMed
概括

下一代RAF抑制剂或"悖论破坏剂"有效地抑制由BRAF突变驱动的癌症生长,而没有悖论性途径激活. 与第一代RAF抑制剂相比,这些新药的疗效提高并克服了耐药性.

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