粘附分子控制淋巴细胞迁移.
1Department of Pathology University of Michigan, Ann Arbor 48109-0602.
Cell
|March 24, 1989
概括
两个粘附分子家族,Hermes/CD44和Mel-14,调解淋巴细胞与血管的相互作用. 这是Mel-14的Mel-14.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 循环的淋巴细胞通过粘附分子与血管壁相互作用.
- 集成蛋白和免疫球蛋白超基因家族是这种相互作用的已知调解者.
研究的目的:
- 描述新发现的粘附分子结构家族.
- 调查它们在淋巴细胞循环和粘附事件中的作用.
主要方法:
- 附着分子家族的结构分析 (Hermes/CD44,Mel-14).
- 与已知的蛋白质结构 (软骨链接蛋白,乳蛋白,EGF,补充结合蛋白) 的序列同质性比较.
主要成果:
- 鉴定了Hermès/CD44家族与软骨链接蛋白的同质性,参与附着于血管床.
- 描述了Mel-14受体与莱克,EGF和补充结合蛋白域的特征,支持淋巴细胞归宿中的莱克-碳水化合物相互作用.
- 将这种结构家族扩展到ELAM-1和GMP-140中,使它们与白细胞和血小板粘附有关.
结论:
- 两个新的粘附分子家族在白细胞-血管壁相互作用中发挥着关键作用.
- 莱克-碳水化合物相互作用在淋巴细胞循环中具有重要意义.
- 这些发现扩大了对免疫细胞贩运中的粘附机制的理解.
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