儿童癌症治疗后的心脏病:一组研究
Nadia Haddy1, Stéphanie Diallo2, Chiraz El-Fayech2
1From Radiation Epidemiology Group, INSERM, UMR1018, Villejuif, France (N.H., C.E.-F., B.S., C.V., O.O., C.G., S.K., I.D., F.d.V.); Gustave Roussy, Villejuif, France (N.H., C.E.-F., B.S., C.V., O.O., C.G., A.B., S.K., E.D., I.D., F.d.V.); Université Paris XI, Villejuif, France (N.H., C.E.-F., B.S., C.V., C.G., I.D., F.d.V.); Centre Hospitalier de Gonesse, Service Pharmacie, Gonesse, France (S.D.); Institut de Cancérologie de l'Ouest, site René Gauducheau CLCC Nantes-Atlantique, Département de Recherche, Saint-Herblain, France (F.P.); Centre for Childhood Cancer Survivor Studies, Department of Public Health & Epidemiology, University of Birmingham, United Kingdom (M.H.); Institut Curie, Paris, France (H.P.); CHU de Reims, Reims, France (M.M.); Institut Jean Godinot, Reims, France (T.D.N'G.); Centre Antoine Lacassagne, Nice, France (P.-Y.B.); Centre Claudius Régaud, Toulouse, France (D.B., A.L.); UMR 1018, University of Paris XI, Villejuif, France (P.-Y.S.); and INSERM U 970, Paris, France (X.J.). nadia.haddy@gustaveroussy.fr.
儿童癌症幸存者接受放射治疗和环素治疗面临心脏病的高风险. 较高的心脏辐射剂量 (HRD) 显著增加了晚年心脏并发症的可能性.
科学领域:
- 心脏病学
- 儿童瘤学
- 辐射瘤学
背景情况:
- 心脏病是儿童癌症治疗的重要长期副作用.
- 儿童治疗期间心脏辐射剂量 (HRD) 与随后的CD风险之间的具体关系之前尚不清楚.
研究的目的:
- 调查儿童癌症治疗期间心脏辐射剂量 (HRD) 与心脏病发病风险之间的关系.
主要方法:
- 研究人员对3162名儿童癌症幸存者进行了分析.
- 收集了化疗数据,并对每个患者估计了心脏辐射剂量 (HRD).
- 用Cox和Poisson回归模型来评估CD风险.
主要成果:
- 在40岁时,任何一种CD的累积发病率为11. 0%,等级≥3CD的累积发病率为7. 4%.
- 与没有人环素和低/ 没有人环素的患者相比,接受人环素和HRD≥30Gy的患者患病风险增加了61.5倍.
- 人类环素治疗和更高的HRD (≥30Gy) 独立地与显著增加的CD风险有关.
结论:
- 儿童癌症幸存者接受放射治疗和人环素治疗时面临患心脏病的剂量依赖风险.
- 心脏病的表现较早出现的患者与没有它.
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