从带到网络:DNA移植的高分子聚合物的层次组织
Yuliia Vyborna1, Mykhailo Vybornyi1, Robert Häner1
1Department of Chemistry and Biochemistry, University of Bern , Freiestrasse 3, CH-3012 Bern, Switzerland.
Journal of the American Chemical Society
|October 23, 2015
概括
通过DNA移植的高分子聚合物使得DNA能够精确地组织. 补充DNA触发网络形成,这是可逆的,提供对纳米结构的动态控制.
科学领域:
- 超分子化学
- 材料科学
- 纳米技术
背景情况:
- 通过DNA移植的超分子聚合物 (SPs) 提供了一个可编程分子组织的平台.
- 氧核酸可以精确地沿着聚合物脊柱排列.
研究的目的:
- 调查DNA移植的SPs在扩展网络中的组装和拆卸.
- 探索补充性寡核酸和基配对相互作用在网络形成中的作用.
主要方法:
- 基于pyrene的螺旋聚合物的合成与移植的寡核酸.
- 使用光谱方法对纳米带组合和网络形成的描述.
- 通过热变性和加分线进行网络可逆性的研究.
主要成果:
- 添加互补的寡核酸诱导了单个纳米丝带组装成扩展的超分子网络.
- 网络形成是由终端GC基对的协同轴叠加驱动的.
- 在网络形成过程中,光谱分析揭示了聚合物核心的结构变化.
- 通过热变性或添加DNA分离链可逆地实现网络拆卸.
结论:
- 用DNA移植的SP提供了一个多功能系统来创建动态的,一维的超分子组件.
- 编程组装和可逆网络形成表明了响应性纳米材料的潜力.
- 这种方法可以控制DNA纳米结构的组织和操纵.
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