共同发育的细胞调节小鼠的REM/非REM睡眠和清醒状态
Yu Hayashi1, Mitsuaki Kashiwagi2, Kosuke Yasuda3
1International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai Tsukuba, Ibaraki 305-8575, Japan. Japan Science and Technology Agency (JST), PRESTO, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan. hayashi.yu.fp@u.tsukuba.ac.jp sitohara@brain.riken.jp.
Science (New York, N.Y.)
|October 24, 2015
概括
研究人员确定了控制快速眼动 (REM) 和非REM (NREM) 睡眠之间的特定脑干神经元. 这些发现揭示了睡眠和清醒周期的复杂调节.
科学领域:
- 神经科学
- 睡眠研究
- 哺乳动物生理学
背景情况:
- 哺乳动物的睡眠一般分为快速眼动 (REM) 和非REM (NREM) 睡眠.
- 脑干内有复杂的神经网络, 对于调节睡眠和清醒状态至关重要.
- 在睡眠阶段之间切换所涉及的特定神经元群体的识别仍然是一个挑战.
研究的目的:
- 在功能上隔离和描述负责调节REM和NREM睡眠过渡的脑干神经元.
- 研究参与睡眠调节的神经元的发育起源.
主要方法:
- 在小鼠中利用化学基因操纵来选择特定胚胎细胞系的神经元.
- 研究了确定的神经元群体在促进或抑制REM和NREM睡眠中的作用.
- 通过追踪表达特定发育基因的神经元群体 (Atoh1) 检查了发育起源.
主要成果:
- 已确定抑制REM睡眠和促进NREM睡眠的刺激性谷氨酸性神经元.
- 发现这些调节睡眠的神经元与促进清醒的神经元具有共同的发育起源,起源于Atoh1表达的后脑细胞.
- 已发现抑制性GABAerg神经元,也抑制REM睡眠.
- 证明人工操纵REM睡眠时间会影响随后的NREM睡眠慢波活动.
结论:
- 大脑干中的特定的谷氨酸和GABAergic神经元群体在调节REM和NREM睡眠中起着至关重要的作用.
- 这些睡眠调节神经元与唤醒神经元有着共同的发育起源.
- 雷姆睡眠积极影响NREM睡眠的调节,这表明睡眠阶段之间的动态相互作用.
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