妊娠前与先天性心脏缺陷之间的联系
Nathalie Auger1, William D Fraser2, Jessica Healy-Profitós3
1Institut national de santé publique du Québec, Montreal, Quebec, Canada2Department of Social and Preventive Medicine, University of Montreal, Montreal, Quebec, Canada3University of Montreal Hospital Research Centre, Montreal, Quebec, Canada.
孕前 (怀孕期间高血压) 与婴儿非临界先天性心脏缺陷的风险增加有关. 虽然整体风险仍然很低,但早产子前也会增加严重心脏缺陷的风险.
科学领域:
- 产科和妇科
- 儿童心脏病学
- 生殖健康
背景情况:
- 孕前与先天性心脏缺陷有共同的血管生成途径,但它们之间的关系尚未完全理解.
- 了解这种联系对于母亲和婴儿的健康结果至关重要.
研究的目的:
- 为了确定先天性心脏缺陷的发病率.
- 研究妊娠前和特定类型的先天性心脏缺陷之间的关联.
主要方法:
- 在加拿大北克省 (1989-2012) 的活生生的人口分析包括超过190万名新生儿.
- 对婴儿进行了临界和非临界先天性心脏缺陷的评估,将暴露于妊娠前的婴儿与未暴露的婴儿进行了比较.
- 在妊娠34周之前或之后出现的预先怀孕症.
主要成果:
- 患有妊娠前的母亲的婴儿患有先天性心脏缺陷的绝对患病率更高.
- 在孕前和非关键性心脏缺陷,特别是隔膜缺陷之间发现了显著的关联.
- 早期发生的妊娠前 (在34周之前) 与严重心脏缺陷的患病率显著增加有关.
结论:
- 孕前与后代非临界先天性心脏缺陷的风险增加有关.
- 早期发生的妊娠前 (< 34 周) 与严重先天性心脏缺陷的更高患病率有关.
- 尽管存在关联,但患有妊娠前的婴儿的总体心脏缺陷风险仍然很低.
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