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Updated: Mar 31, 2026

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针对C-Jun N-终端激酶的门卫MET146诱导双等/键

Andreas Lange1,2, Marcel Günther3, Felix Michael Büttner4

  • 1Molecular Design and Pharmaceutical Biophysics, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen , Auf der Morgenstelle 8, 72076 Tübingen, Germany.

Journal of the American Chemical Society
|October 28, 2015
PubMed
概括

药物设计中的素键可以增强对c-Jun N-终端激酶3 (JNK3) 抑制剂的选择性,即使亲和力没有增加. 这项研究强调了特定的素选择如何针对独特的激酶特征以更好地开发药物.

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