用于调节跨膜质子转移动性的光响应分子开关
Ying Li1, Edmund C M Tse1, Christopher J Barile1
1Department of Chemistry, University of Illinois at Urbana-Champaign , 600 South Mathews Avenue, Urbana, Illinois 61801, United States.
Journal of the American Chemical Society
|October 30, 2015
概括
研究人员开发了一种光激活的分子开关, 这种光响应性质子门可以使用特定的光波长来反向打开和关闭,从而能够精确地控制功能设备的质子传递.
科学领域:
- 生物化学
- 材料科学
- 摄影化学
背景情况:
- 通过生物膜进行质子传输对于许多细胞过程至关重要.
- 开发控制质子流的方法对于人工细胞系统和生物灵感设备至关重要.
- 现有的控制质子传递的方法往往缺乏时空精度.
研究的目的:
- 合成和表征一个光响应分子开关,用于控制质子传递.
- 将这个开关整合到脂质层中, 创建一个光门的质子传输系统.
- 通过光来证明反向激活和关闭质子流.
主要方法:
- 一个新型的光响应分子开关的合成.
- 将开关纳入脂质双层膜.
- 用特定的光波长 (390nm和360nm) 辐射以诱导E-Z和Z-E异构.
- 监测脂肪埋藏电催化剂的质子流和催化活性.
主要成果:
- 合成的分子开关在照射时显示了E和Z异构体之间的可逆光异构化.
- 质子门成功地控制了通过脂质层的质子流,
- 光诱导的质子输送系统使得脂埋氧减氧电催化剂的可逆切换成为可能.
结论:
- 一个响应光的分子开关可以有效地控制穿过膜的质子传递.
- 这种光诱导的膜质子输送系统提供了对质子流的精确时空控制.
- 开发的系统有可能用于开发利用质子合电子转移反应的功能设备.
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