由大肠杆菌介导的疾病耐受性涉及炎症和IGF-1信号
Alexandria M Palaferri Schieber1, Yujung Michelle Lee1, Max W Chang2
1Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
概括
一种特定的肠道细菌,大肠杆菌, 这种开始性微生物维持了关键的生长因子信号, 保护骨肌肉免受疾病诱导的缩.
科学领域:
- 微生物学
- 免疫学
- 生理学
背景情况:
- 感染和炎症会导致骨肌肉和脂肪组织的消耗.
- 感染引起的肌肉衰竭的确切机制尚未完全理解.
- 开始性肠道细菌可能在调节宿主对感染的反应中发挥作用.
研究的目的:
- 研究特定肠道大肠杆菌菌株在感染期间预防肌肉损耗的作用.
- 阐明这种大肠杆菌对消耗的保护的分子机制.
主要方法:
- 用特定的大肠杆菌菌株殖民小鼠,并接受各种感染模式 (沙门氏菌Typhimurium,Burkholderia thailandensis).
- 分析了宿主的新陈代谢,热量摄取,炎症和骨肌肉信号通路.
- 评估了NLRC4炎症酶在保护作用中的作用.
主要成果:
- 在感染了S. Typhimurium或B. thailandensis的小鼠中,用特定的大肠杆菌菌株植入肠道,可以防止骨肌肉消耗.
- 在没有改变宿主代谢,热量摄取或全身炎症的情况下观察到这种保护作用.
- 大肠杆菌在骨肌肉中维持了类似胰岛素的生长因子1/酸丁3-激酶/AKT信号通路,这对于预防肌肉缩至关重要.
- 保护作用取决于NLRC4炎症酶的参与.
结论:
- 一种开始性肠道大肠杆菌菌株可以防止疾病引起的肌肉损耗.
- 这种保护通过通过NLRC4炎症体维持骨肌肉生长因子信号传递.
- 通过调节特定的分子通路,共生细菌可以促进宿主对各种疾病的耐受性.
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