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相关概念视频

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
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Olfaction01:25

Olfaction

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The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
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相关实验视频

Updated: Mar 30, 2026

Rapid Dissection and Dissociation of the Mouse Olfactory Epithelium for Single-Nucleus Suspensions
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Rapid Dissection and Dissociation of the Mouse Olfactory Epithelium for Single-Nucleus Suspensions

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单细胞转录学揭示了嗅觉神经发生过程中的受体转化

Naresh K Hanchate1, Kunio Kondoh1, Zhonghua Lu1

  • 1Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

Science (New York, N.Y.)
|November 7, 2015
PubMed
概括

成熟的小鼠嗅觉神经元表达单个嗅觉受体基因, 不像不成熟的神经元表达多个. 这种对嗅觉至关重要的发育过程似乎独立于神经元活动.

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Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor
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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay
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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay

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Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor
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科学领域:

  • 神经科学
  • 遗传学
  • 嗅觉系统的发展

背景情况:

  • 嗅觉依赖于嗅觉神经元检测各种化学物质的气味.
  • 嗅觉神经元表达特定的嗅觉受体基因 (Olfrs) 来实现这种多样性.

研究的目的:

  • 研究小鼠嗅觉神经元成熟的发育机制.
  • 了解神经元发育过程中单细胞Olfr基因表达是如何建立的.

主要方法:

  • 使用单个神经元RNA测序.
  • 分析小鼠鼻腔嗅觉神经元中的基因表达模式.

主要成果:

  • 成熟的神经元主要在高水平上表达单个Olfr基因 (约1000个基因可用).
  • 不成熟的神经元在低水平上共同表达多个Olfr基因,来自各种染色体.
  • 同表达的Olfrs在鼻上皮表内显示区域偏差,但不是单个基因组位点.

结论:

  • 嗅觉神经元的成熟涉及发展的进展,限制Olfr基因表达到每个神经元中的一个.
  • 这一关键的发展步骤似乎独立于神经元活动和感官传导.