皮质运动神经元"功能调整"
Darcy M Griffin1, Donna S Hoffman2, Peter L Strick3
1University of Pittsburgh Brain Institute, Center for the Neural Basis of Cognition and Systems Neuroscience Institute, Pittsburgh, PA, USA. Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Science (New York, N.Y.)
|November 7, 2015
概括
主要运动皮层中的皮质运动神经元 (CM) 细胞直接影响运动输出. 不同的CM细胞群控制着不同的肌肉功能,这表明运动皮层输出编码肌肉使用.
科学领域:
- 神经科学
- 发动机控制
- 计算神经科学
背景情况:
- 主要运动皮层 (M1) 中的皮层神经元 (CM) 细胞直接激活运动神经元,为运动控制提供关键的下降途径.
- 了解CM细胞如何促进复杂的运动行为,包括多样化的肌肉招募,对于破译运动命令至关重要.
研究的目的:
- 研究CM细胞在产生肌肉活动中的作用.
- 确定特定的CM细胞群是否与目标肌肉的不同功能作用相关 (激动剂,协同作用剂,固定剂,抗剂).
主要方法:
- 分析不同运动任务中的肌肉激活相关的CM细胞活动.
- 将CM细胞的偏好方向与它们的目标肌肉的功能作用进行比较.
主要成果:
- 许多CM细胞的偏好方向与目标肌肉的主要作用不一致.
- 不同的CM细胞群体表现出针对特定肌肉功能的选择性活性,如激动性,协同性,固定性或对抗性.
结论:
- 单个肌肉的不同功能可能是由单独的CM细胞群组成的.
- 主动皮层的输出可能代表肌肉功能作为运动控制的关键维度.
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