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通过Sestrin2-mTORC1途径进行白检测的结构基础

Robert A Saxton1, Kevin E Knockenhauer2, Rachel L Wolfson1

  • 1Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA. Howard Hughes Medical Institute, Department of Biology, MIT, Cambridge, MA 02139, USA. Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.

Science (New York, N.Y.)
|November 21, 2015
PubMed
概括

研究人员阐明了Sestrin2的素结合机制,这是拉巴胺复合物1 (mTORC1) 途径的关键传感器,揭示了细胞如何感知营养的可用性.

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