替代了加多,用于MRI对比度
Eric M Gale1, Iliyana P Atanasova1, Francesco Blasi1
1The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School , 149 Thirteenth Street, Suite 2301, Charlestown, Massachusetts 02129, United States.
Journal of the American Chemical Society
|November 21, 2015
概括
一种新的复合物为患有脏疾病的患者提供了加多对比剂的更安全替代品. 这种以为基础的成像探针表现出稳定性和有效的清除,显示出在脆弱人群中诊断血管异常的前景.
科学领域:
- 医疗成像医学成像
- 放射化学 放射化学是指辐射化学.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 对比增强型计算机断层扫描 (CT) 和磁共振成像 (MRI) 对于诊断软组织和血管问题的重要.
- 基于和加多 (Gd) 的对比剂对慢性病 (CKD) 患者构成安全风险.
- 对于与功能障碍相容的安全对比剂,存在重大未满足的需求.
研究的目的:
- 引入一种新的 (II) 复合物[Mn (PyC3A) (H2O) ],作为潜在的加多替代品.
- 为了评估[Mn{PyC3A}{H2O}}{-}的稳定性,放松性和生物分布.
- 开发和评估纤维素向探头 (Mn-FBP) 以进行增强的血栓成像.
主要方法:
- (II) 复合物[Mn (PyC3A) (H2O) ]的合成和表征.
- 在离子的存在下对解离的复杂稳定性的评估.
- 在血和生物分布研究中测量放松性.
- 将复合物修改为双功能合剂,并与纤维素特异性 (Mn-FBP) 结合.
- 评估Mn-FBP与纤维素的结合亲和力及其在大鼠动脉血栓形成模型中的表现.
主要成果:
- [Mn ((PyC3A)) ((H2O)))))) 与加多类似物相比,具有较高的稳定性和抗解离性.
- 该复合物表现出与商业Gd药物相似的放松性,并通过混合/肝胆道途径有效清除.
- Mn-FBP对纤维素具有很高的亲和力,在结合时增强放松性,并在体内提供有效的血栓增强.
- 对于探头,没有观察到脱皮的证据,在24小时内消除>99%.
结论:
- [Mn ((PyC3A)) ((H2O)))))) 是一个有前途的领先候选人,适用于脏受损患者的新一类MRI对比剂.
- 纤维素向的探头Mn-FBP为血栓瘤检测提供了改进的成像能力.
- 基于的对比剂对大量患者群体来说,代表了加多的更安全的替代品.
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