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中枢桃体中的Htr2a表达细胞控制着天生的恐惧与学习的恐惧之间的等级
Tomoko Isosaka1, Tomohiko Matsuo1, Takashi Yamaguchi2
1Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan; Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan.
Cell
|November 23, 2015
概括
这种恐惧刺激可以抑制学习到的恐惧反应. 中枢桃体中的血清素-2A受体细胞优先考虑与生俱来的恐惧,而不是学习到的恐惧,作为一个等级生成器.
科学领域:
- 神经科学
- 行为神经科学
- 恐惧的调节
背景情况:
- 恐惧反应通过不同的先天和学会的途径进行调解.
- 了解这些途径的整合对于理解恐惧处理至关重要.
- 中枢桃体 (CeA) 参与恐惧调节.
研究的目的:
- 通过嗅觉介导的范式来研究先天和学会的恐惧路径的整合.
- 确定控制先天性恐惧与学习恐惧之间的神经机制.
- 阐明特定神经元群体在优先考虑恐惧反应中的作用.
主要方法:
- 嗅觉介导的先天性恐惧与学会恐惧模式在小鼠中.
- 整个大脑的映射和药物查.
- 在体内光纤测量以监测神经元活动.
- 有关特定细胞群的人工失活.
主要成果:
- 之前的先天性恐惧刺激抑制了学习的恐惧反应,
- 在CeA中,表达氨酸-2A受体 (Htr2a) 的细胞有差异性地控制先天和学会的结.
- 本来存在的恐惧刺激抑制了表达Htr2a的CeA细胞活动.
- 表达Htr2a的CeA细胞的无活化对先天的结产生了上调,对学习的结产生了下调.
结论:
- 在CEA中表达Htr2a的细胞作为一个层次生成器,优先考虑先天的恐惧而不是学会的恐惧.
- 这些细胞整合了感官输入以调节基于恐惧类型的行为输出.
- 这些发现揭示了大脑中恐惧反应优先级的新机制.
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