多巴胺神经元编码对象的长期记忆对习惯性行为有价值
Hyoung F Kim1, Ali Ghazizadeh2, Okihide Hikosaka3
1Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA; Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon 440-746, Republic of Korea; Department of Biomedical Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
Cell
|November 23, 2015
概括
研究人员在黑色物质中发现了一种新型的多巴胺神经元, 稳定地保留学习的奖励值, 促进习惯行为. 这一发现揭示了长期记忆和习惯形成的神经基础.
科学领域:
- 神经科学
- 行为科学
背景情况:
- 多巴胺神经元通常会对奖励值的最近变化发出信号以最大限度地提高结果.
- 灵活的奖励信号不足以维持习惯性行为,尽管奖励的波动仍然存在.
研究的目的:
- 确定参与稳定保留学习奖励值的多巴胺神经元群.
- 研究习惯性行为和长期价值记忆的神经机制.
主要方法:
- 在子中进行的电生理记录黑色物质密集体 (SNc).
- 分析多巴胺神经元对视觉对象的反应,并学习奖励值.
- 从SNC多巴胺神经元到尾状核的预测.
主要成果:
- 在尾侧SNC中发现"维持类型"多巴胺神经元.
- 这些神经元根据所学到的奖励值对物体保持不同的反应,即使没有即时的奖励.
- 通过学习来加强反应,并在最初的获取后持续很长时间.
- 这些神经元会投射到尾部, 这个区域参与长期价值记忆.
结论:
- 在SNC中,多巴胺神经元的独特群体选择性地促进习惯性行为的学习和保留.
- 这些"维持类型"神经元有助于长期价值记忆和自动引导到有价值的对象.
- 这些发现揭示了多巴胺神经元在灵活的学习和稳定的习惯形成中发挥的双重作用.
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