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单细胞基因组学揭示了Th17细胞致病性的关键调节者

Jellert T Gaublomme1, Nir Yosef2, Youjin Lee3

  • 1Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA; Department of Physics, Harvard University, 17 Oxford Street, Cambridge, MA 02138, USA.

Cell
|November 27, 2015
PubMed
概括

在自身免疫性脑膜炎 (EAE) 中,研究T助手17 (Th17) 细胞异质性揭示了致病性的分子驱动因素. 这种细胞多样性可以引导向疗法抑制有害的Th17细胞,同时保留有益的Th17细胞.

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