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STAT3 在心脏β-上腺功能中的关键作用

Wenjun Zhang1, Xiuxia Qu2, Biyi Chen2

  • 1From State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (W. Zhang, X.Q., Y.T., W.S.); Riley Heart Research Center, Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indianapolis, IN (W. Zhang, B.L., H.C., W. Zhu, L.Z., N.Y., D.L., L.X., Y.L., M.R., W.S.); Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City (B.C., L.-S.S.); Department of Physiology and Biophysics, Cornell University Weill Medical College, New York, NY (M.S., J.J.Z., X.-Y.H.); Department of Surgery, Indiana University School of Medicine, Indianapolis (M.W.); Department of Pharmacology, Harbin Medical University, Harbin, China (B.L.); Department of Heart Surgery, Xiangya 2nd Hospital, Central South University, Changsha, China (N.Y., L.X.); and Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis (X.-Y.F.). wenjun08@gmail.com wenzhang@iu.edu wnshou@gmail.com wshou@iu.edu.

Circulation
|December 3, 2015
PubMed
概括

信号转换器和转录3激活器 (STAT3) 对心脏β上腺素受体 (βAR) 信号传递至关重要. STAT3 调节心脏功能,应对压力,并防止病态重塑,突出其在心力衰竭中的作用.

关键词:
STAT3转录因子心脏衰竭与G蛋白结合的受体上腺体受体

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