在感冒期间,肠道微生物调节能量恒温
Claire Chevalier1, Ozren Stojanović1, Didier J Colin2
1Department of Cell Physiology and Metabolism, Centre Médical Universitaire (CMU), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes Centre, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.
Cell
|December 7, 2015
概括
寒冷会重塑肠道微生物群,提高胰岛素敏感性,促进脂肪变黑. 这种"寒冷的微生物群"也增加了营养吸收,在寒冷的条件下帮助能量平衡.
科学领域:
- 微生物学
- 主体与微生物群的相互作用
- 代谢生理学
背景情况:
- 由于共同进化,宿主生理与微生物组成密切相关.
- 温度等环境因素可以显著影响肠道微生物群.
研究的目的:
- 研究寒冷暴露对肠道微生物组成的影响.
- 确定寒冷诱导的微生物群转移对宿主生理学的功能后果,特别是能量稳态.
主要方法:
- 暴露在寒冷中的小鼠.
- 将便微生物移植到没有细菌的小鼠身上.
- 评估宿主代谢参数,包括胰岛素敏感性和脂肪色.
- 肠道形态和基因表达的分析.
- 研究特定细菌菌株的作用,如Akkermansia muciniphila.
主要成果:
- 暴露在寒冷环境下会产生独特的肠道微生物群组成 ("寒冷微生物群").
- 植入"寒冷微生物群"可以改善胰岛素敏感性,促进白色脂肪的色,增加能量消耗,并促进寒冷耐受性.
- 长期暴露于寒冷会导致肠道吸收表面积的适应性增加,可通过"寒冷微生物群"转移.
- 似乎可以调节"寒冷微生物群"对肠道重塑和亡的影响.
结论:
- 在应对寒冷等环境挑战时,肠道微生物群在主体能量稳定中起着至关重要的作用.
- 寒冷引起的微生物群变化可以调解显著的生理适应,包括提高代谢效率和能源消耗.
- 适应寒冷的微生物群中的特定微生物物种在调节宿主肠道适应和能量平衡方面具有不同的作用.
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