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使用L-RNA阿普塔默的微RNA处理的特定抑制

Jonathan T Sczepanski1, Gerald F Joyce1

  • 1Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Journal of the American Chemical Society
|December 15, 2015
PubMed
概括

研究人员开发了微RNA (miRNA) 处理的胺抑制剂. 这些aptamiRs与前体miRNAs结合,阻断Dicer酶的活性并防止成熟miRNA的形成,从而提供了一种新的治疗策略.

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