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Updated: Mar 28, 2026

Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets
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在不对称的细胞分裂过程中通过螺旋体不对称的极化内分体动力学

Emmanuel Derivery1, Carole Seum1, Alicia Daeden1

  • 1Department of Biochemistry, Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, Geneva 1211, Switzerland.

Nature
|December 15, 2015
PubMed
概括

研究人员发现Sara (受体激活的Smad) 内分体如何在细胞分裂过程中不对称地分离. 一个kinesin电机将内分体向一个极化,引导它们的不平等分布到子细胞中.

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Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
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The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of...
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Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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