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  1. 首页
  2. 患有新发性心房动的血液透析患者的死亡和中风风险:全国性队列的竞争风险分析
  1. 首页
  2. 患有新发性心房动的血液透析患者的死亡和中风风险:全国性队列的竞争风险分析

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患有新发性心房动的血液透析患者的死亡和中风风险:全国性队列的竞争风险分析

Chia-Jen Shih1, Shuo-Ming Ou1, Pei-Wen Chao1

  • 1From School of Medicine, National Yang-Ming University, Taipei, Taiwan (C.-J.S., S.-M.O., S.-C.K., Y.-J.L., C.-Y.Y., D.-C.T., C.-C.L., P.-H.H., S.-Y.L., Y.-T.C.); Department of Medicine, Taipei Veterans General Hospital, Yuanshan Branch, Yilan, Taiwan (C.-J.S.); Deran Clinic, Yilan, Taiwan (C.-J.S.); Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan (S.-M.O., C.-Y.Y., D.-C.T., C.-C.L., S.-Y.L.); Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan (S.-M.O., Y.-T.C.); Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan (P.-W.C.); School of Medicine, Taipei Medical University, Taipei, Taiwan (P.-W.C.); National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan (S.-C.K.); Division of Infectious Diseases, Taipei Veterans General Hospital, Taipei, Taiwan (S.-C.K.); Department of Neurology, Taipei City Hospital, Ren Ai Branch, Taipei, Taiwan (Y.-J.L.); Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan (P.-H.H.); and Division of Nephrology, Department of Medicine, Taipei City Hospital, Heping Fuyou Branch, Taipei, Taiwan (Y.-T.C.).

Circulation
|December 19, 2015

在PubMed 上查看摘要

概括
此摘要是机器生成的。

患有新发性心房动的血液透析患者的中风风险略有增加,但在考虑住院死亡时,这种风险变得微不足道. 这一发现影响了该群体使用抗凝剂的考虑.

关键词:
心房动死亡透析流行病学没有风险一次中风

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科学领域:

  • 肝脏病学
  • 心脏病学
  • 流行病学

背景情况:

  • 由于风险与益处不清楚,在血液透析患者中使用口服抗凝剂存在争议.
  • 对于抗凝剂在高危人群中的净益处存在不确定性.

研究的目的:

  • 与没有心律失常的患者相比,研究血液透析患者新发性肌痛风暴的缺血性中风风险
  • 在接受血液透析的患者中评估心血管事件风险.

主要方法:

  • 全国范围,以人口为基础,倾向性得分匹配的队列研究.
  • 使用台湾国家健康保险研究数据库 (1998-2011).
  • 包括接受血液透析的非膜肌痛新发患者和没有心律失常的匹配对照.

主要成果:

  • 患有AF的患者 (n=6772) 患有缺血性中风 (aHR,1. 27),因任何原因死亡 (aHR,1. 59) 和心力衰竭住院 (aHR,1. 90) 的风险较高.
  • 当在医院死亡被认为是竞争风险时,AF显著增加心力衰竭风险 (HR,1. 56),而不是缺血性中风或心肌梗塞.
  • 在竞争风险模型中,缺血性中风的CHA2DS2- VASc得分的预测值有所降低.

结论:

  • 血液透析患者的中风风险与没有中风的患者相比仅略有增加.
  • 这种增加的中风风险在医院死亡的竞争风险中变得无关紧要.
  • 这些发现表明,在这个特定的患者群体中重新评估抗凝剂治疗的益处.