协调和细分的神经调节 塑造虫的感官处理
Raphael Cohn1, Ianessa Morantte1, Vanessa Ruta1
1Laboratory of Neurophysiology and Behavior, The Rockefeller University, New York, NY 10065, USA.
Cell
|December 22, 2015
概括
体作为神经调节器, 通过神经调节, 根据环境和经验将气味信号导向不同的行为. 这种电路机制使灵活的适应性行为成为可能.
科学领域:
- 神经科学
- 动物的行为
- 分子生物学
背景情况:
- 学习和适应性行为依赖于神经回路,可以将感官输入与各种输出联系起来.
- 体是参与嗅觉处理和行为的一个关键大脑区域.
研究的目的:
- 调查Drosophila体中神经调节在调解行为灵活性中的作用.
- 了解嗅觉信号如何转向不同的行为回路.
主要方法:
- 在Drosophila的功能性突触成像.
- 电生理学研究神经活动.
- 研究突触传输的多巴胺基调节.
主要成果:
- 的身体就像一个电路调节器,
- 多巴胺基输入以高空间特异性调节突触传输.
- 多巴胺神经元形成一个编码外部和内部状态以协调可塑性.
结论:
- 具有突触精度的神经调节网络可以将单个感官输入转化为多样化的输出模式.
- 这为行为灵活性提供了通用电路机制.
- 这些发现为适应性行为的神经基础提供了洞察力.
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