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可以通过可见到NIR光作为有前途的生物活性分子来激活的无过渡金属CO释放的BODIPY衍生物

Eduardo Palao¹, Tomáš Slanina¹, Lucie Muchová

¹Department of Chemistry and RECETOX, Masaryk University , Kamenice 5, 625 00 Brno, Czech Republic.

Journal of the American Chemical Society

|December 25, 2015

概括

研究人员使用BODIPY开发了新的无过渡金属一氧化碳释放分子 (CORM). 这些分子为各种应用提供了可见到NIR光激活的一氧化碳释放的精确控制.

科学领域:

有机化学
摄影化学
生物医学工程

背景情况:

一氧化碳释放分子 (CORM) 对于提供一氧化碳 (CO),一种内源信号分子至关重要.
精确的空间和时间控制CO释放对于有效的CORM应用至关重要.
现有的CORM通常依赖于过渡金属,限制其范围.

研究的目的:

根据BODIPY染色体 (COR-BDPs) 合成和描述一种新的无过渡金属CORM类.
调查这些新CORM的光触发CO释放机制.
在体外和体内模型中评估COR-BDP的有效性.

主要方法:

基于BODIPY的一氧化碳释放分子 (COR-BDP) 的合成.
使用可见至近红外 (NIR) 光 (高达730nm) 的光化学激活.
光谱研究 (稳态和瞬态) 和量子化学计算以阐明CO释放机制.
在体外和体内性能评估.

主要成果:

基于BODIPY结构的无过渡金属CORM的成功合成.
由可见到NIR光激活的光触发的一氧化碳释放.
在体外和体内实验环境中证实了性能.
通过光谱和计算分析阐明了CO释放机制.

结论:

新一代无过渡金属CORM (COR-BDP) 已经开发出来.
这些COR-BDP提供基于光的精确控制CO释放,扩大治疗和研究的可能性.
这些发现为开发使用可控CO输送的先进光药学工具提供了基础.

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