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在IDH突变质瘤中隔离器功能障碍和瘤基因激活

William A Flavahan1,2,3, Yotam Drier1,2,3, Brian B Liau1,2,3

  • 1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

Nature
|December 25, 2015
PubMed
概括

质瘤中的IDH突变破坏了DNA甲基化和CTCF结合,导致异常基因激活并促进瘤生长. 这种表观遗传破坏会影响染色体拓和瘤基因表达.

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