与体外受精治疗周期重复相关的活产率
Andrew D A C Smith1,2, Kate Tilling1,2, Scott M Nelson3
1Medical Research Council Integrative Epidemiology Unit at the University of Bristol, UK.
JAMA
|December 31, 2015
概括
在重复体外受精 (IVF) 后,活产的可能性很大,六个周期后累计活产率为65. 3%. 这些发现支持将IVF治疗扩展到通常限定的三到四个胚胎移植之外.
科学领域:
- 生殖医学
- 治疗不孕症
- 临床试验
背景情况:
- 复制体外受精 (IVF) 的活产率尚未得到充分证实.
- 目前的试管婴儿治疗方案通常限制患者进行3或4次胚胎移植.
研究的目的:
- 为了确定每个开始的卵巢刺激试管婴儿周期的活产率.
- 用重复试管婴儿周期来评估累积活产率.
主要方法:
- 对156,947名接受257,398次试管婴儿周期 (2003-2010) 的英国妇女进行前性研究.
- 在2012年6月之前的后续行动.
- 将IVF周期定义为卵巢刺激和随后的所有新鲜/冷胚胎移植.
主要成果:
- 第一个试管婴儿的活产率为29.5%,在第四个试管婴儿周期中仍然超过20%.
- 经预后调整后的活产率在第六个周期达到65. 3%.
- 根据年龄的不同,年轻女性 (<40岁) 的成功率更高.
结论:
- 在6次试管婴儿周期后,经过预后调整后,累计活产率为65. 3%.
- 这些发现支持将试管婴儿治疗延长至3-4个周期的疗效.
- 活产率受患者年龄和特定治疗类型的影响.
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