脑前皮层调节全脑电路动态和与奖励相关的行为
Emily A Ferenczi1,2, Kelly A Zalocusky1,2, Conor Liston3
1Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
概括
中间前额皮层 (mPFC) 通过控制大脑区域之间的相互作用来调节寻求奖励的行为. 慢性mPFC过度活动抑制了奖励动机,并预测了精神障碍的症状.
科学领域:
- 神经科学
- 行为神经科学
- 精神病学研究
背景情况:
- 奖励驱动了适应性行为.
- 抑郁症和精神分裂症都有关联.
- 中间前额皮层 (mPFC) 参与享乐反应.
研究的目的:
- 测试mPFC是否控制控制享乐反应的皮下区域之间的相互作用.
- 调查奖励处理和快乐的基础的神经机制.
主要方法:
- 在老鼠中进行光遗传功能磁共振成像 (MRI).
- 局部操纵神经活动与全球可视化结合.
- 导致慢性mPFC过度活动.
主要成果:
- 多巴胺神经元刺激增加了条形状活动.
- 增加的mPFC刺激性降低了条纹性反应和对多巴胺的行为驱动.
- 慢性mPFC过度活动抑制了奖励动机的行为,并改变了大脑的功能相互作用.
- 这些相互作用预测了快乐的程度.
结论:
- mPFC通过调节皮质下区域之间的动态相互作用来调节寻求奖励的行为.
- 在精神疾病中,mPFC过度活跃可能是无情的机制.
- 这些发现为控制动机和奖励的神经回路提供了洞察力.
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