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癌症中VHL无活化的ID2依赖机制

Sang Bae Lee1, Veronique Frattini1, Mukesh Bansal2,3

  • 1Institute for Cancer Genetics, Columbia University Medical Center, New York 10032, USA.

Nature
|January 7, 2016
PubMed
概括

DYRK1激酶通过化ID2来调节癌症干细胞的维持,这会影响HIF2α的稳定性. 这一发现为质母细胞瘤和其他癌症提供了新的治疗点.

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