星球细胞通过Hevin桥接NRX1α和NL1组装甲状腺突触
Sandeep K Singh1, Jeff A Stogsdill1, Nisha S Pulimood2
1Department of Cell Biology, Duke University Medical Center, Durham, NC 27710.
Cell
|January 16, 2016
概括
星细胞分泌的黑蛋白桥梁神经素-1α和神经素-1B,形成关键的突触连接. 这一发现揭示了星细胞如何调节突触形成,并可能影响神经发育障碍.
科学领域:
- 神经科学
- 分子生物学
- 发育生物学
背景情况:
- 突触形成依赖于突触前神经素和突触后神经素之间的相互作用.
- 神经和神经的特定异型决定了直接的突触相互作用.
- 细胞外链蛋白在扩大这些相互作用中的作用以前是未知的.
研究的目的:
- 研究细胞外链接蛋白是否可以扩展神经素-神经素相互作用代码.
- 确定一个由星细胞分泌的蛋白质hevin在突触组合中的功能.
主要方法:
- 在体外生化测试以研究蛋白质相互作用.
- 在视觉皮层模型开发中的体内研究.
- 对突触形成和可塑性的分析.
主要成果:
- 河与神经素-1α和神经素-1B形成桥梁,这些同位素没有直接相互作用.
- 这种hevin介导的桥梁对于谷氨酸突触组合至关重要.
- 希文对于视觉皮层中乳皮层连接的形成和可塑性至关重要.
结论:
- 星球细胞通过赫分泌调节神经素/神经素粘附以促进突触形成.
- 希文扩展了突触粘附的分子代码.
- 在像自闭症这样的疾病中, 肝素,神经素或神经素的突变可能会导致电路功能障碍.
相关概念视频
Neuron Structure
21.2K
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
21.2K
Glial Cells
96.6K
Overview
96.6K
The Synapse
137.8K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
137.8K
Fusion of Secretory Vesicles with the Plasma Membrane
19.3K
Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
19.3K
Synaptic Signaling
7.1K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
7.1K
Synaptic Signaling
81.6K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
81.6K


