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Updated: Mar 26, 2026

In Vitro Analysis of E3 Ubiquitin Ligase Function
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一个HOIP/E2~ubiquitin复合物的结构揭示了RBR E3连接酶机制和调节

Bernhard C Lechtenberg1, Akhil Rajput2, Ruslan Sanishvili3

  • 1NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

Nature
|January 21, 2016
PubMed
概括

研究人员发现了活性HOIP RING-between-RING (RBR) E3结合酶的结构. 这一发现阐明了RBR E3链酶在泛素转移中的机制,揭示了类似HECT的过程和新的泛素结合位点.

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