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持续的HIV-1复制在治疗期间保持组织储存

Ramon Lorenzo-Redondo¹, Helen R Fryer², Trevor Bedford³

¹Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60011, USA.

|January 28, 2016

概括

即使病毒载量无法检测,人类免疫缺陷病毒1型 (HIV-1) 仍在淋巴组织中复制. 尽管有强大的抗逆转录病毒疗法,但这种持续的病毒活动和储体进化可能会发生.

科学领域:

病毒学
免疫学
传染性疾病

背景情况:

淋巴组织是急性感染期间出现的人类免疫缺陷病毒1型 (HIV-1) 的关键储存库.
这种组织参与病毒的产生,免疫复合体的储存和长期病毒的持久性.
结合抗逆转录病毒疗法 (cART) 在这些存储库中完全抑制病毒复制的有效性仍然不确定.

研究的目的:

尽管在cART期间无法检测到血病毒RNA水平,但HIV-1复制和进化是否在淋巴组织储存中持续存在.
开发一个空间和动态模型,以了解病毒在这些水库中的持续复制和传播.
在药物度不足的情况下阐明病毒演变和耐药性发展的机制.

主要方法:

在无法检测的cART患者中分析病毒演变和组织内流通.
开发和应用一个空间和动态模型来模拟持续的病毒复制和传播.
在低于最佳的药物度下影响耐药性发展的因素的调查.

主要成果:

在未检测到的血液病毒水平的患者中,观察到病毒的演变和组织间的流通继续.
一个空间和动态模型表明病毒在淋巴组织储存中持续复制和传播.
这些发现表明,即使药物度不足以完全阻止复制,药物耐药性也可能是不可避免的.

结论:

即使在强烈的抗逆转录病毒治疗中,HIV-1 病毒也可以继续在淋巴组织中复制和补充其储备.
库内持续的病毒复制和进化挑战了cART完全抑制病毒的假设.
这些发现为HIV-1在治疗过程中的复杂进化和感染动态提供了新的见解.

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