在V型高脂血症中使用gemfibrozil的低脂效应. 这是一项双盲交叉研究
D A Leaf1, W E Connor, D R Illingworth
1Department of Medicine, Oregon Health Sciences University, Portland 97201.
JAMA
|December 8, 1989
概括
米布罗齐尔有效降低V型高脂血症患者的甘油三和胆固醇. 这种低脂剂耐受性很好,有助于在低脂肪饮食的同时治疗严重的高甘油三血症.
科学领域:
- 心脏病学 心脏病学
- 代谢障碍 代谢障碍 代谢障碍
- 药理学 药理学 是一个学科.
背景情况:
- 五型高脂血症是一种严重的遗传性疾病,其特征是甘油三和胆固醇水平升高.
- 对V型高脂血症的有效管理策略对于预防心血管并发症至关重要.
研究的目的:
- 为了评估米布罗西尔在治疗V型高脂血症患者中的疗效和耐受性.
- 评估米布罗西尔对血脂质谱的影响,包括甘油三,总胆固醇,LDL-C和HDL-C.
主要方法:
- 一项随机,双盲,交叉研究,涉及13名V型高脂血症患者.
- 患者在两次8周的时间内接受了gemfibrozil或安慰剂,分隔4周的洗期.
- 4周的低脂肪饮食基线在研究之前作为饮食对照.
主要成果:
- 与安慰剂相比,gemfibrozil显著降低了血总甘油三和非常低密度脂蛋白甘油三.
- 血中总胆固醇和非常低密度脂蛋白胆固醇水平也被gemfibrozil显著降低.
- 胆米克隆血症几乎被消除,并且观察到低密度脂蛋白胆固醇和高密度脂蛋白胆固醇的增加.
结论:
- 米布罗齐尔是一种耐受性良好且有效的低脂剂,用于治疗V型高脂血症患者的严重高甘油三血症.
- 建议用gemfibrozil和低脂肪饮食进行联合治疗,以实现最佳的脂质管理.
- 米布罗齐尔在减少异位性脂蛋白的显著益处,同时改善整体脂质状况.
相关概念视频
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
01:24Lipid Absorption
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
01:15Bioavailability Study Design: Healthy Subjects Versus Patients
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
01:08Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...