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通过基底细胞对脑干运动回路进行细胞类型特定的控制
Thomas K Roseberry1, A Moses Lee2, Arnaud L Lalive3
1The Gladstone Institutes, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
Cell
|January 30, 2016
概括
通过调节特定的大脑干神经元来控制运动. 直接和间接的途径激活或抑制这些神经元,从而启动或抑制运动.
科学领域:
- 神经科学
- 发动机控制
- 系统神经科学
背景情况:
- 基底 (BG) 对于自适应运动控制至关重要.
- 了解BG通路如何调节像中脑运动区域 (MLR) 这样的目标区域对于解读运动控制机制至关重要.
研究的目的:
- 调查BG直接和间接路径控制移动的MLR的电路机制.
- 阐明不同MLR细胞类型在BG运动控制中的作用.
主要方法:
- 对MLR神经元子群的光遗传学剖析 (谷氨基基,GABA基,胆能基).
- 研究BG途径与MLR细胞类型的相互作用.
- 评估对运动行为的影响.
主要成果:
- MLR质神经元编码运动状态和速度,对于运动是必要的和足够的,并接受选择性的BG内化.
- 直接的BG途径激活了MLR质神经元,而间接的途径则抑制了它们.
- 这种差分调制可以通过BG电路双向控制运动.
结论:
- 通过细胞类型特定的MLR神经元调节启动或抑制运动程序.
- 提供了关于运动启动和抑制的神经基础的基本见解.
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