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K C Nicolaou1, Jun Yin1, Debashis Mandal1

  • 1Department of Chemistry, BioScience Research Collaborative, and Department of Chemical and Biomolecular Engineering, Rice University , 6100 Main Street, Houston, Texas 77005, United States.

Journal of the American Chemical Society
|February 2, 2016
PubMed
概括

研究人员开发了有效的合成途径,发现了Tb32等强效化合物. 这些新型细胞毒剂对向癌症治疗和抗体药物联合物具有前景.

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Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...