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吸烟者中呼吸道崩与呼吸道结果之间的关联
Surya P Bhatt1, Nina L J Terry2, Hrudaya Nath2
1Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham2UAB Lung Health Center, University of Alabama at Birmingham3UAB Lung Imaging Core, University of Alabama at Birmingham.
JAMA
|February 3, 2016
概括
吸烟者中枢呼吸道崩 (ECAC) 与呼吸质量降低和恶化有关. 这一发现强调了ECAC是吸烟者呼吸系统健康的重要因素.
科学领域:
- 肺部医学
- 放射学
- 呼吸系统健康
背景情况:
- 呼气中心气道崩 (ECAC),定义为呼吸道光面积在呼气过程中减少50%以上,与吸烟和COPD有关.
- ECAC的患病率和临床意义在很大程度上是未知的.
研究的目的:
- 独立于潜在的肺部疾病,研究ECAC与吸烟者的呼吸道疾病之间的关联.
- 确定ECAC对生活质量,呼吸障碍,运动能力和恶化的频率的影响.
主要方法:
- 分析了COPDGene研究 (8820名当前/前吸烟者) 中的吸气-呼气CT扫描.
- 对气管直径减少>30%进行定量查,然后进行手动测量以确认ECAC (>50%的面积减少).
- 评估基线呼吸质量 (SGRQ),呼吸障碍 (mMRC),6分钟步行距离和纵向恶化频率.
主要成果:
- 在5%的参与者中存在ECAC.
- 与COPD无关的ECAC与呼吸质量恶化 (SGRQ得分) 和呼吸障碍增加 (mMRC得分) 有关.
- 患有ECAC的参与者更频繁地出现需要住院治疗的总体和严重恶化.
结论:
- 在吸烟者中,ECAC是一种普遍的疾病,与呼吸质量下降有关.
- 这些发现表明ECAC有助于吸烟者的呼吸道疾病,包括恶化.
- 需要进一步研究以充分阐明ECAC的长期临床影响.
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