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Updated: Mar 26, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

Published on: December 7, 2014

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基因特异性抑制剂通过捕获机制使突变KRAS G12C失活

Piro Lito1, Martha Solomon2, Lian-Sheng Li3

  • 1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. rosenn@mskcc.org litop@mskcc.org.

Science (New York, N.Y.)
|February 4, 2016
PubMed
概括

新疗法可以通过将蛋白质在不活跃状态中来抑制KRAS (G12C) 信号传递,需要完整的瓜诺辛三酸酶 (GTPase) 活性. 这种机制为治疗KRAS ((G12C) 驱动的癌症提供了一种新方法.

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