细胞,味道化学感应细胞,在肠道中调节寄生虫2型免疫力
Michael R Howitt1, Sydney Lavoie1, Monia Michaud1
1Departments of Immunology and Infectious Diseases and Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
概括
在寄生虫感染期间, 肠细胞起着哨兵的作用. 它们释放介素-25,促进对肠道寄生虫的第二类免疫力.
科学领域:
- 免疫学
- 胃肠病学
- 细胞生物学
背景情况:
- 肠道上皮是对肠道微生物群的重要障碍.
- 表皮细胞对原生菌和虫等真核肠道微生物的反应作用尚未完全理解.
研究的目的:
- 研究肠细胞在宿主对寄生虫感染反应中的作用.
- 阐明细胞对肠道寄生虫的免疫机制.
主要方法:
- 在寄生虫殖民期间对细胞种群的观察研究.
- 化学传感信号的遗传破坏 (TRMP5敲除).
- 细胞因子分析 (互白素-25和互白素-13) 和细胞群评估 (状细胞,杯状细胞,乙酸细胞,2型先天性淋巴细胞).
主要成果:
- 在寄生虫殖民和感染过程中,
- 失去了TRMP5介导的化学传感信号,阻止了细胞,杯细胞,乙酸细胞和2型先天性淋巴细胞的扩张.
- 细胞被认为是寄生虫诱导的中白素-25的主要来源.
- 通过刺激先天性淋巴细胞的干白素-13产生,干白素-25间接促进细胞扩张.
结论:
- 肠细胞是肠表皮中的关键哨兵.
- 细胞通过介质素-25/介质素-13轴启动和放大对肠道寄生虫的2型免疫反应.
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