相关实验视频

Updated: Mar 26, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

人类肺瘤中的代谢异质性

Christopher T Hensley¹, Brandon Faubert¹, Qing Yuan²

¹Children's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

|February 9, 2016

概括

非小细胞肺癌 (NSCLC) 在体内表现出代谢异质性. 瘤利用葡萄糖和其他营养素, 受到其微环境的影响, 揭示复杂的代谢途径.

科学领域:

癌症学
代谢学
癌症生物学

背景情况:

非小细胞肺癌 (NSCLC) 在影响细胞代谢的遗传和环境因素方面表现出显著的异质性.
了解体内瘤代谢对于开发有效的癌症疗法至关重要.

研究的目的:

在体内研究人类NSCLC的代谢特征.
为了比较NSCLC瘤和邻近的良性肺组织之间的营养利用.
为了确定NSCLC瘤内部和之间的代谢异质性.

主要方法:

在手术期间,C- 葡萄糖输注给了9名NSCLC患者.
对瘤和良性肺组织样本进行了代谢分析.
使用稳定同位素追踪来追踪营养代谢.

主要成果:

在大多数NSCLC瘤中观察到增强的糖解和葡萄糖氧化.
在瘤中发现了包括乳酸在内的多种营养物的氧化证据.
在瘤内和瘤之间发现了代谢异质的区域.
在瘤透良好的区域建议提供非葡萄糖营养素.

结论:

在体内NSCLC的代谢是高度异质的,在瘤内和瘤之间存在差异.
瘤的新陈代谢受到周围微环境的显著影响.
乳酸和其他非葡萄糖营养素可以作为NSCLC的碳来源.

更多相关视频

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Published on: October 25, 2011

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues

Published on: June 16, 2018

相关概念视频

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...