一种双热反应的双胞胎类型超两分子 [3]基于柱体[10]arene/Paraquat合作复合物的伪多素
Xiaodong Chi1, Guocan Yu1, Li Shao1
1State Key Laboratory of Chemical Engineering, Center for Chemistry of High-Performance & Novel Materials, Department of Chemistry, Zhejiang University , Hangzhou 310027, PR China.
Journal of the American Chemical Society
|February 11, 2016
概括
研究人员使用pillararene和paraquat制造了一种新型双热响应的超分子聚合物. 这种材料自组装成囊泡,用于受控释放的应用,由温度变化触发.
科学领域:
- 超分子化学
- 聚合物科学
- 材料化学
背景情况:
- 柱状体是宏循环的主体,可调节的腔体大小.
- 热敏聚合物随着温度的变化而改变性质.
- 超分子组件提供了动态和响应性的材料.
研究的目的:
- 使用柱状和酸衍生物制备热敏 [3] 伪.
- 构建第一个基于pilararene的双子类型的超两性 [3] 伪多素.
- 调查合成的大分子伪素的自我组装和受控释放能力.
主要方法:
- 在水性介质中进行合作复合.
- 合成含有帕奎特的多胺 (N-异烯胺).
- makromolecular pseudorotaxane 的特征及其自组装成囊泡.
- 对双热反应和受控释放的温度依赖性研究.
主要成果:
- 成功制备了一种热反应 [3] 伪多素.
- 一种新型基于pilarene的双胞胎类型的超两性 [3]伪多的构造.
- 展示了独特的双热反应行为.
- 在37°C形成聚合物囊泡.
- 由温度变化 (25 °C和 60 °C) 引发的小分子的受控释放.
结论:
- 合成的大分子 [3] 伪多多具有双热反应性质.
- 这种材料可以自组成囊泡,用于潜在的药物输送应用.
- 温度诱导的变化有效控制封装分子的释放.
相关概念视频
01:17Thermal Electrocyclic Reactions: Stereochemistry
2.7K
The stereochemistry of electrocyclic reactions is strongly influenced by the orbital symmetry of the polyene HOMO. Under thermal conditions, the reaction proceeds via the ground-state HOMO.
Selection Rules: Thermal Activation
Conjugated systems containing an even number of π-electron pairs undergo a conrotatory ring closure. For example, thermal electrocyclization of (2E,4E)-2,4-hexadiene, a conjugated diene containing two π-electron pairs, gives trans-3,4-dimethylcyclobutene.
Selection Rules: Thermal Activation
Conjugated systems containing an even number of π-electron pairs undergo a conrotatory ring closure. For example, thermal electrocyclization of (2E,4E)-2,4-hexadiene, a conjugated diene containing two π-electron pairs, gives trans-3,4-dimethylcyclobutene.
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01:26Thermal and Photochemical Electrocyclic Reactions: Overview
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Electrocyclic reactions are reversible reactions. They involve an intramolecular cyclization or ring-opening of a conjugated polyene. Shown below are two examples of electrocyclic reactions. In the first reaction, the formation of the cyclic product is favored. In contrast, in the second reaction, ring-opening is favored due to the high ring strain associated with cyclobutene formation.
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