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在体和脑脊液之间进行T细胞贩运

Christian Schläger¹, Henrike Körner¹, Martin Krueger²

¹Institute of Neuroimmunology, Institute for Multiple Sclerosis Research, University Medical Centre Göttingen, 37073 Göttingen, Germany.

|February 11, 2016

概括

在多发性硬化症中,T细胞从脑脊液进入脑脊液,较少活化的细胞优先释放到脑脊液. 这些T细胞可以重新进入中枢神经,导致炎症.

科学领域:

神经免疫学
细胞生物学
炎症研究

背景情况:

多发性硬化症涉及T细胞侵入中枢神经系统 (CNS),导致炎症.
在脑膜,脑膜和脑脊液 (CSF) 中发现T细胞.
脑脊髓中T细胞的确切路径和功能尚不清楚.

研究的目的:

调查效应性T细胞是如何从体细胞进入脑脊液的.
确定脑脊髓中T细胞的激活状态和潜力.
阐明控制中枢神经和中枢神经系统间T细胞流通的机制.

主要方法:

使用了路易斯大鼠自身免疫脑炎 (EAE) 实验模型.
分析了T细胞的运动和Leptomeningeal网络中的相互作用.
评估了T细胞基因表达和脑性潜力.
研究了整合素 (VLA-4,LFA-1) 和化学激素信号 (CCR5/CXCR3) 在T细胞粘附中的作用.

主要成果:

在EAE期间,观察到效应体T细胞从体中进入脑脊液.
脱离到脑脊液的T细胞的激活率较低,但仍具有脑致死性.
综合素结合和化学激素信号介导T细胞粘附到瘦肉细胞巨细胞.
脑脊液中的T细胞可能会重新连接到脑膜,并入侵脑膜.

结论:

体细胞作为T细胞进入中枢神经系统的关键检查点.
较少激活的T细胞优先释放到脑脊液中,可能迁移到受损区域.
T细胞可以在脑脊液和中枢神经系统间传播,从而影响多发性硬化症的疾病进展.

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