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相关概念视频

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
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没有扩散的多能性

Xiaodong Shu1, Duanqing Pei1

  • 1Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.

Cell
|February 13, 2016
PubMed
概括
此摘要是机器生成的。

Myc 枯竭导致小鼠胚胎干细胞 (mESC) 进入休眠状态,类似于隔离状态. 这种状态保留了多能性,同时将其与细胞增殖程序脱.

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科学领域:

  • 干细胞生物学
  • 发育生物学
  • 表观遗传学

背景情况:

  • 小鼠胚胎干细胞 (mESC) 具有无限的增殖能力,并保持多能性.
  • 在mESC中,细胞增殖和多能性通常是相关的.
  • 了解这些状态的调节对于发育生物学来说至关重要.

研究的目的:

  • 研究Myc在调控mESC增殖和多能性的作用.
  • 为了确定多能性是否可以独立于增殖.
  • 探索Myc,休眠和多能性保护之间的联系.

主要方法:

  • 在小鼠胚胎干细胞中减少Myc.
  • 细胞增殖率的评估
  • 多能性标记分析
  • 与胚胎间隔状态进行比较.

主要成果:

  • 在mESC中诱导了休眠状态.
  • 这种休眠状态类似于胚胎间歇.
  • 在休眠的mESC中,多能性完全保留.
  • 微生物消耗有效地将多能性与扩散脱.

结论:

  • Myc对于维持mESC的繁殖计划至关重要.
  • 多能性可以维持在静止状态,使其脱离扩散.
  • 这一发现为干细胞调控和发育停止提供了新的见解.