形成和检索印制的嗅觉记忆的不同电路
Xin Jin1, Navin Pokala1, Cornelia I Bargmann1
1Howard Hughes Medical Institute (HHMI), Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA.
Cell
|February 13, 2016
概括
在C. elegans的早期生活经历创造了持久的记忆. 新的虫接触到病原体会产生持续的厌恶,与成年人不同,突出了早期的学习时期.
科学领域:
- 神经科学
- 行为生物学
- 发育生物学
背景情况:
- 早期的经历深深地影响了长期的行为和记忆.
- 早期记忆形成的稳定性和机制尚未完全理解.
研究的目的:
- 研究早期C. elegans长期记忆形成的机制.
- 为了区分早期印象和成年人学习的厌恶记忆.
主要方法:
- 新化和成年C. elegans暴露于致病细菌.
- 行为测试以测量反感记忆的持续性.
- 参与记忆的神经回路和神经调节剂 (氨酸,SER-2受体) 的遗传分析.
主要成果:
- 新化的C. elegans对特定的致病细菌表现出持续的厌恶,而成年人暴露会产生暂时的厌恶.
- 在第一个幼虫阶段 (L1) 存在着对印记厌恶的关键学习期.
- 不同的神经通路 (AIB,RIM用于形成;AIY,RIA用于检索) 和胺信号对L1刻印记忆至关重要.
- AIY神经元中的SER-2受体对于印制的厌恶检索至关重要.
结论:
- 早期暴露通过不同的神经元机制在C. elegans中建立了一个稳定的,病原体特异性的厌恶记忆.
- 氨酸和SER-2受体在记忆的形成和检索中起着至关重要的作用.
- 这些发现阐明了早期学习和记忆的神经生物学基础.
相关概念视频
Physiology of Smell and Olfactory Pathway
14.0K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
14.0K
Olfaction
49.8K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
49.8K
Olfactory Receptors: Location and Structure
14.2K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
14.2K
Functional Brain Systems: Limbic System
8.9K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
8.9K
Imprinting
11.5K
Behavioral imprinting is observed in some newborn animals and occurs when they develop strong and specific attachments to another animal (usually a parent) following brief, early-life exposures. Offspring imprint onto parents within a brief period after birth or hatching; this time window is called the critical period. Once imprinting occurs, the bond established between the parents and their offspring is usually long-lasting.
11.5K


