对祖先脊椎动物大脑复杂区域化的循环体证据
Fumiaki Sugahara1,2, Juan Pascual-Anaya1, Yasuhiro Oisi3
1Evolutionary Morphology Laboratory, RIKEN, Kobe 650-0047, Japan.
Nature
|February 16, 2016
概括
脊椎动物的大脑
科学领域:
- 进化发育生物学
- 神经科学
- 比较基因组学
背景情况:
- 复杂的脊椎动物大脑的进化起源尚未得到充分理解.
- 由于缺少发育基因表达域,Lamprey胚胎大脑被认为代表一个祖先状态.
- 和Nkx2.1域的缺失与中枢突突出损失有关.
研究的目的:
- 研究脊椎动物大脑区域化的进化历史.
- 确定早期脊椎动物血统中是否保留了关键的大脑发育领域.
- 重新评估脊椎动物大脑的原始状态.
主要方法:
- 对鱼和鱼胚胎大脑发育的比较分析.
- 在循环体大脑中的基因表达模式分析.
- 对大脑结构的组织学检查.
主要成果:
- 鱼的大脑表现出相当于中间状突起和状唇的域,类似于体.
- 幼虫具有这些以前被认为是缺失的发育领域.
- 这些发现表明大脑区域化模式得到了保护.
结论:
- 主要的大脑区域化特征并不仅限于体.
- 在鱼和鱼中观察到的大脑发育领域表明它们的起源很古老.
- 复杂的大脑区域化早于循环体和体的分化,可以追溯到5亿多年前.
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