游泳诱导的肺:病理生理学和使用西尔德纳菲尔降低风险
Richard E Moon1, Stefanie D Martina2, Dionne F Peacher2
1From Department of Anesthesiology, and Center for Hyperbaric Medicine & Environmental Physiology, Duke University Medical Center, Durham, NC (R.E.M., S.D.M., D.F.P., J.F.P., T.E.W., A.D.C., M.J.N., C.E.O., D.N.K., W.D.W., J.J.F.); Department of Medicine, Duke University Medical Center, Durham, NC (R.E.M.); Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia (D.F.P.); Department of Anesthesiology, University of Virginia, Charlottesville (J.F.P.); Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston (T.E.W.); Delaware County Memorial Hospital, Drexel Hill, PA (C.E.O.); and Institute for Human & Machine Cognition, Pensacola, FL (D.N.K.). richard.moon@duke.edu.
游泳引起的肺 (SIPE) 涉及在水下运动期间肺动脉压力升高. 在易受影响的个体中,西尔德纳菲尔有效地降低了这些压力,这表明它有预防SIPE的潜力.
科学领域:
- 心血管生理学
- 肺部医学
- 运动生理学
背景情况:
- 游泳引起的肺 (SIPE) 是一种影响游泳者和潜水者的疾病.
- 病理生理不清楚,通常发生在年轻,健康的个体中.
研究的目的:
- 测试SIPE敏感个体在潜水运动期间是否有较高的肺动脉和压.
- 确定西尔德纳菲尔是否可以降低这些高血压.
主要方法:
- 在10名易受SIPE感染的受试者和20名受试者中使用了动脉和肺动脉导管.
- 试验对象在20°C的水中进行了适度循环运动.
- 在服用50毫克西尔德纳菲尔后,对SIPE敏感的人重复运动.
主要成果:
- 与对照组相比,对SIPE敏感的个体在运动期间的肺动脉平均压力 (34. 0 vs 22. 5 mm Hg) 和肺动脉形压力 (18. 8 vs 11. 0 mm Hg) 显著增加.
- 心脏输出在易受SIPE影响的受试者中较低 (13. 8 vs 17. 9 L·min-1).
- 在易受SIPE感染的患者中,西尔德纳菲尔使肺动脉压力正常化,并没有产生不良的血液动力学影响.
结论:
- 证实SIPE是一种血液动态肺.
- 西尔德纳菲尔降低肺血管压力的能力表明它在预防SIPE方面具有潜在的效用.
相关概念视频
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Pulmonary Embolism I: Introduction
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Pulmonary Embolism III: Nursing Management
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Mitral Stenosis IV: Nursing Management


