中期发育过渡和动物身体计划的演变
Michal Levin1, Leon Anavy1, Alison G Cole1
1Department of Biology, Technion - Israel Institute of Technion, Haifa 32000, Israel.
Nature
|February 18, 2016
概括
基于身体计划的动物分类,可以通过在发育中期的转变过程中保存的基因表达来客观地定义. 这种过渡连接了早期和晚期的基因表达阶段,可能会在各种物种中定义类型时期.
科学领域:
- 发育生物学
- 进化生物学
- 基因组学
背景情况:
- 动物类传统上是由不同的身体计划定义的.
- 类型时期是一个保存的发育阶段,存在于某些类型中.
- 目前对类的定义缺乏客观标准,导致任意分组.
研究的目的:
- 调查定义动物类的客观标准.
- 探索基因表达在类定义中的作用.
- 在不同动物物种中比较发育转录组.
主要方法:
- 十种不同类型的发育转录组的比较分析.
- 在发育过程中识别保存和分离的基因表达模式.
- 基因表达过渡与已知的类型周期的相关性.
主要成果:
- 十种物种都表现出保存的早期和晚期基因表达.
- 一个不同的"中期发展过渡"通过特定物种的途径连接这些阶段.
- 这种过渡与类型期重叠,表明它在体型形成中的作用.
结论:
- 中期发育过渡对于确定类型的身体计划至关重要.
- 这种过渡可以用来定义其他类型中的类型时期.
- 一个基因组可以通过在发育中期的转变过程中保留而又独特的基因表达来定义.
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